That patient’s treatment course was complicated by severe anemia (the lowest hemoglobin level was 6.9 g/dL), which led to use erythropoietin, and a reduction of RBV from 800 mg/day to 600 mg/day in the first half of treatment and a further decrease to 400 mg/day in the latter half of treatment. Here, EPO is linked to anemia (phenotype).