INS and cancer: The possibility that insulin analogues have a different effect on the incidence of cancer than human insulin, has been a reason for concern since the 1990s, when the clinical development of the rapid-acting analogue AspB10 had to be terminated because of the risk for malignancies - an effect attributed to a lower dissociation rate from the insulin receptor and/or to a higher affinity for the IGF-1 receptor (23).