PDIA2 is upregulated in SH-SY5Y human neuroblastoma treated with either 1-methy-4-phenyl-pyridinium (MPP+) or proteasome inhibitor lactacystin while immunoreactivity to PDIA2 has also been detected in LB in postmortem brains of PD patients [146]. This evidence concerns the gene PDIA2 and Parkinson disease.