When only patients with macroadenomas were analyzed, ΔGHmax-min during the TST were significantly higher in TRH responders (105.8 ± 138.1 versus 34.8 ± 30.1 μg/L, P = 0.024: P value not shown in the table), while tumor volumes were not significantly different. The gene discussed is TRH; the disease is neoplasm.