GH1 and acromegaly: However, the detailed mechanism of the paradoxical response of GH to TRH in acromegaly remains unknown despite a number of possible hypotheses: local production of TRH by adenoma cells [11, 12], TRH-induced release of GH [13], TRH production by anterior pituitary gland [14], and inappropriate expression of TRH receptors at tumor cells [15].