In addition, a variety of agents such as FK506-entrapped nanoparticles [29], viral and nonviral NF-κB decoys [30, 31], blockade of CD30-CD30L interaction [32], IL-25 [33], leptin [34], and a plant-derived compound [35] have been shown to ameliorate both colitis models. The gene discussed is LEP; the disease is colitis.