FTO and obesity due to melanocortin 4 receptor deficiency: This would appear consistent with our unique observation of a negative association of obesity-predisposing FTO alleles with cardiomyopathy [p(corr) = 0.0009, OR = 0.53 (95% CI 0.37–0.77)] that could result in lower expression of FTO; although further studies with larger sample sizes are necessary to confirm or refute this finding.