CCR7 and neoplasm: While it represent a component of the “gold standard” cocktail for vaccine DC maturation (61) due to its role in promoting CCR7-mediated migration (62), and it also induces the expression of costimulatory molecules like OX40-L and CD70 promoting T cell functions (63, 64), it can inhibit the synthesis of IL-12p70 (65), while favoring the secretion of IL-23 that promote Th17 immune responses (66) and tumor development (67, 68).