All of the animal models of rotavirus infection and disease (horse, cow, sheep, gnotobiotic piglet, rat, and mouse) exhibit the same primary tropism of virus to the small intestinal epithelial cells, excretion of the virus in the stool, kinetics of infection, most severe disease in the young, and induction of rotavirus-specific intestinal IgA that correlates with clearance of infection and protective immunity (129–149). Here, CD79A is linked to infection.