There has been some indication, using methods that involve expansion of single rotavirus-specific circulating B cells, that there is low number of somatic hypermutation in circulating rotavirus-specific IgA+ B cells isolated from infants and adults that have previously experienced a rotavirus infection and that VH1–46 is the immunodominant gene segment, except in CD5+ B cells in young children (212–214). Here, CD79A is linked to Rotavirus infection.