In the classical model of peripheral T cell activation, tissue-resident dendritic cells (DCs) capture antigens (such as foreign pathogens, tumor cell debris, etc.)in an inflammatory microenvironment, leading to the migration of antigen-laden CCR7+ DC to regional draining lymph nodes [LN; aka secondary lymphoid organs (SLO)], where activation of cognate T cells occurs (1–3). This evidence concerns the gene CCR7 and neoplasm.