For example, targeted therapeutic delivery of LTα into the TME via the administration of a fusion protein encompassing the LTα molecule linked to an antibody recognizing a tumor plasma membrane-associated disialoganglioside GD2 (i.e., ch14.18-LTα) resulted in slowed tumor progression and the establishment of mature TLO structures within 9 days of treatment initiation (8). The gene discussed is LTA; the disease is neoplasm.