CCL21 and neoplasm: Indeed, ectopic expression of LIGHT in the TME elicits profound infiltration and cross-priming of naïve anti-tumor T cells in concert with upregulated stromal cell production of TLO-associated chemokines (CCL21, CXCL9, CXCL10, and CXCL13), increased expression of vascular adhesion molecules (MAdCAM-1, VCAM-1, PNAd), and the presence of mature DC within the TME (9).