For instance, mice vaccinated sub-cutaneously with syngenic DC loaded with apoptotic/necrotic B16 melanoma cell debris develop operational TLO [pseudocapsule; PNAd+ vascular endothelial cells (VEC), T cell/DC infiltrates] at sites of injection, leading to the activation of protective anti-tumor immunity (72). The gene discussed is NTAN1; the disease is neoplasm.