EDN1 and Hypertension: Enhanced vascular gene expressions of ET-1 and ETA receptor, and an amelioration of hypertension via administration of selective ETA receptor antagonist observed previously in our fructose-induced hypertensive rats (18) and in comprehensive reviews (15, 37, 38) suggested that ETA receptor may play a role in the regulation of BP and consequently its antagonists may become one of the therapeutic strategies in clinical.