On the contrary, some other polymorphisms of ETS have been shown to be associated with BP either directly or in interaction with other genes/factors, for example C1363T in exon 8 of the ETA receptor on pulse pressure of normotension (24), G198T in exon 5 of the ET-1 gene together with BMI on BP (26), and A985G in 3′-untranslated region of the ET-2 gene on the severity of hypertension (41). The gene discussed is EDN2; the disease is hypertensive disorder.