DTNBP1 and schizophrenia: In schizophrenia patients, dysregulation of glutamatergic transmission and reduced expression of dysbindin were reported (Mechri et al., 2001; Talbot et al., 2004, 2006; Weickert et al., 2004, 2008; Tang et al., 2009), suggesting that dysfunction of dysbindin may result in failure of homeostatic plasticity mechanisms tuning glutamatergic transmission.