Recent findings show that the motor neurons of ALS model mice display altered expression of some Wnt effectors, such as Wnt1, Wnt2, Wnt5a, Fz1, and Fz2 (Chen et al., 2012; Li et al., 2013; Wang et al., 2013). The gene discussed is WNT5A; the disease is amyotrophic lateral sclerosis.