ISL1 and amyotrophic lateral sclerosis: Our findings show that control cells display a constitutive expression of Islet-1 and induce the expression of Hb9 upon differentiation; however, whereas Islet-1 levels are similar in both cell lines, the expression of Hb9 is significantly impaired in ALS-like cells, indicating that the consolidation of motor neuronal identity might be compromised.