SOD1 and amyotrophic lateral sclerosis: Even though most ALS cases are sporadic, a 5–10% of them have a genetic linkage, as they are associated to point mutations of several proteins, such as Cu/Zn superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TDP43), Fused in Sarcoma (FUS), senataxin (SETX), amongst others (Bruijn et al., 2004; Schymick et al., 2007; Robberecht and Philips, 2013).