In a BDNF heterozygous mouse model, Manning and van den Buuse investigated the effects of chronic methamphetamine treatment during late adolescence/early adulthood on a behavioral endophenotype related to the positive symptoms of schizophrenia, prepulse inhibition (PPI) of the acoustic startle reflex (Manning and van den Buuse, 2013). This evidence concerns the gene BDNF and schizophrenia.