We previously demonstrated that activation of Wnt signaling inhibits GSK-3β, and leads to neuroprotection in both hippocampal cultured neurons and in vivo transgenic model of AD (Garrido et al., 2002; Inestrosa et al., 2002; De Ferrari et al., 2003; Alvarez et al., 2004; Quintanilla et al., 2005). This evidence concerns the gene GSK3B and Alzheimer disease.