APP and spinocerebellar ataxia type 8: Abnormal splicing of multiple exons in microtubule associated protein tau (MAPT), and exon 7 in the amyloid precursor protein (APP) and exon 5 in glutamate receptor NMDAR1, have been detected in brains of DM1 patients and mouse models (Jiang et al., 2004; Gomes-Pereira et al., 2007) and analogous splicing alterations have been shown in SCA8 mice (Daughters et al., 2009) which may explain neurological alterations in these diseases.