ATXN7 and Huntington disease: Bidirectional transcription has been detected in many TREDs loci including, DM1, SCA8, FXTAS, SCA7, HDL2, and HD, suggesting a role in disease pathogenesis (Table 1; Cho et al., 2005; Ladd et al., 2007; Batra et al., 2010; Chung et al., 2011; Sopher et al., 2011; Wilburn et al., 2011; Seixas et al., 2012).