This epigenetic repression involves chromatin modifiers (including the histone H3K9 methyltransferase MET-2 [13] and H3K36 methyltransferase MET-1 that may indirectly promote H3K9 methylation [13], [14]), chromatin readers (including the MBT (malignant brain tumor) domain-containing protein LIN-61 [29], the HP1-like protein HPL-2 [20]), zinc finger protein LIN-13 that helps localize HPL-2 [28]), a novel chromodomain protein CEC-3, a transcriptional repressor EFL-1 [27], and a large, acid-rich protein LIN-65 with unknown function [31]. The gene discussed is PRTN3; the disease is brain neoplasm.