EFL1 and brain neoplasm: The four synMuv B genes were efl-1/E2F, which encodes a transcriptional repressor [27]; lin-13, which encodes a zinc-finger protein that forms a complex with HPL-2 and helps localize HPL-2 to certain genomic loci [28]; lin-61, which encodes a protein with four malignant brain tumor repeats that bind to di- and tri-methylated H3K9 [29], [30] and interacts genetically with hpl-2 and met-2 in vulva development [30]; and lin-65, which encodes a large acid-rich protein that lacks obvious similarity to non-nematode proteins [31].