Ling et al. found that mutation of the H3K9 methyltransferase G9a induced abnormal myogenesis during skeletal muscle differentiation by de-repressing the transcription of myogenic regulatory factor MyoD [61], and Herzog et al. found that the histone demethylase Kdm3a, which removes H3K9 methyl groups, is essential for the differentiation of mouse embryonic carcinoma cells into parietal endoderm-like cells in a mouse embryonal carcinoma model [62]. This evidence concerns the gene KDM3A and embryonal carcinoma.