Among them, the core syndromes are pantothenate kinase-associated neurodegeneration (PKAN, NBIA type 1), which was previously named Hallervorden-Spatz disease and accounts for approximately 50% of NBIA cases [2], and PLA2G6-associated neurodegeneration (PLAN, NBIA type 2). Here, PANK1 is linked to pantothenate kinase-associated neurodegeneration.