It is now known that PLZF is expressed in many cells of the body, and several lines of evidence indicate that PLZF participates in various signaling, growth regulatory, and differentiation pathways, including hematopoiesis, adipogenesis, hippocampal neurogenesis, osteoclastogenesis, and muscle differentiation, and it is involved in diverse functions, such as homeostasis, neoplasia, and apoptosis [10, 11]. The gene discussed is ZBTB16; the disease is neoplasm.