Thus, our observation of decreased serum ADM in children with diabetes of less than 10 years' duration, especially in the context of a weaker response in the S-cone ERG and higher serum levels of VEGF, lipids, and higher blood pressure, seems surprising, even though a substantial increase in the level of ADM has been demonstrated only in patients burdened with overt retinopathy, microalbuminuria, or renal failure [48]. The gene discussed is ADM; the disease is Renal insufficiency.