HFD-fed mice displayed glucose intolerance, with levels of both fasting insulin (supplementary Fig. IIA, P < 0.05) and glucose (supplementary Fig. IIB, P < 0.05) being increased by 3.2 ± 0.5-fold and 1.44 ± 0.7-fold, respectively. This evidence concerns the gene INS and Glucose intolerance.