In contrast, sections from the tumor-bearing side of mice treated with F10 at 120 mg/kg showed no EphA2 staining, even in the necrotic tissue that was the remnants of the malignant mass while only trace levels of EphA2 positive staining were detected in the ventricle of mice treated with F10 at 80 mg/kg (Fig. 5b, c). This evidence concerns the gene EPHA2 and neoplasm.