In addition, it has been demonstrated to reduce endotoxine-induced systemic inflammatory responses, inhibit upregulation of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6 and macrophage inflammatory protein-2 (MIP-2); and relieve acute organ injuries in rats and patients with sepsis (8,9). Here, TNF is linked to Sepsis.