Although previous studies showed DZNep was a global histone methyltransferase inhibitor and not specific for EZH2 inhibition and we can't rule out other unrecognized mechanisms responsible for DZNep-mediated anticancer effects, however, these findings together with others suggested that it yielded its anticancer effects at least in part via disturbing the EZH2 oncogenic pathway irrespective of cancer types[26, 34, 46]. The gene discussed is PRDM9; the disease is cancer.