Further genes in the minimal differentiation set were ZNF217, COL14A1 and DMRT2. ZNF217 is a marker of poor prognosis in breast cancer [65], COL14A1 is a candidate tumor-suppressor gene frequently methylated in renal cell carcinomas [66] and the transcription factor DMRT2 is downregulated in clear-cell renal-cell carcinomas [67]. Here, DMRT2 is linked to hereditary clear cell renal cell carcinoma.