Nuclear p53 was associated with high tumor size (p=0.011), high tumor grade (52.9% in cases with nuclear p53 vs. 31.0% in p53 negative tumors; p=0.001), absence of ER (65.9% vs. 13.9%; p<0.001), HER2 amplification (31.8% vs. 15.5%; p=0.001), high proliferation (35.3% vs. 22.5%) and relapse of the disease (31.8% vs. 16.8%; p=0.003). The gene discussed is ERBB2; the disease is neoplasm.