NFKB1 and breast cancer: In breast cancer, NF-κB has been assigned as a pro-apoptotic pathway through repression of anti-apoptotic genes in response to doxorubicin [25], and in other reports, doxorubicin-induced nuclear p65 cannot be phosphorylated and acetylated and, therefore, its DNA binding affinity and transcriptional activity is reduced [16].