Flow cytometry analysis showed that exposure to SSMC increased the low-MITF population (70% to 300%) in 501mel, G361, MeWo and WM9 cell lines, which have different BRAF mutational status (Supplementary Fig. S1B), and in melanoma cells isolated from patient skin metastasis expressing wild type BRAF, in which SSMC (black line) led to a 4-fold increase in the percentage of the low-MITF population (0.72 to 2.93%) (Fig. 1E). The gene discussed is MITF; the disease is melanoma.