Familial pancreatic cancer represents approximately 5 % of all newly diagnosed PDA Genetic predisposition to PDA is polygenic; seen individuals with mutations in Fanconi anemia pathway genes (BRCA2, BRCA1, and PALB2), DNA mismatch repair genes (MSH2, MSH6, MLH1, and PMS2), CDK2A/p16 (FAMMM syndrome), PRSS1 (hereditary pancreatitis), and LKB1/STK11 (Puetz-Jeghers) [51]. This evidence concerns the gene PMS2 and Patent ductus arteriosus.