While AD did not have any significant effect on the levels of LOX metabolites, fisetin significantly reduced the levels of pro-inflammatory 5-hydroxyeicosatetraenoic acid (5-HETE) and 12-hydroxyeicosatetraenoic acid (12-HETE), the primary metabolites of 5-LOX and 12-LOX, respectively, in the AD mice. Here, ALOX5 is linked to Alzheimer disease.