E2F1 and lung adenocarcinoma: In our work, the integrative analysis of a series of smoker and non-smoker lung adenocarcinoma data sets shows that E2F1 might regulate a gene module enriched for cell cycle related genes, in turn, partially explain the molecular differences between smoker and non-smoker lung adenocarcinoma and different response to chemotherapies between smoker and non-smoker lung adenocarcinoma.