These structural chromosome abnormalities and a variety of molecular defects including gene mutations affecting JAK2, MPL, TET2, LNK, EZH2, NF1, IDH1, IDH2, CBL, ASXL1, IKAROS and NF-E2 are prevalent but not specific to any subset of MPN and have been described in other myeloid disorders [6,7]. This evidence concerns the gene JAK2 and myeloproliferative disorder.