CTSD and neoplasm: The multivariate analysis further demonstrated that the lymph node status (HR: 3.69, 95% CI: 2.23-6.11, P<0.001), Cathepsin-D (HR: 2.12, 95% CI: 1.05-4.28, P=0.035) and Ki-67 index (HR: 1.74, 95% CI: 1.07-2.84, P=0.025) remained to be independent prognostic factors , while menopausal status, tumor stage and histologic grade did not have statistical significance.