Because of the (patho)physiological role of FAs in metabolism, this altered FA-uptake has been suggested to explain the association of FABP2 with increased insulin resistance and FA-oxidation, supporting observations suggesting a role of the FABP2 Ala54Thr-polymorphism in CVD-etiology (e.g. increased waist circumference and atherosclerosis) [21–25]. The gene discussed is FABP2; the disease is Insulin resistance.