NEDD4 and central nervous system cancer: We found that shNEDD4-1 cannot down-regulate the large amount of exogenous NEDD4-1 anymore and the exogenous NEDD4-1 can abolish the inhibition effect of shNEDD4-1 on glioma cell migration both in U251 and U87, suggesting that the effect of shNEDD4-1 on cell migration was specific (*P<0.01, Figure S1A and S1B).