We have shown that a DNA demethylating agent DAC, but not the histone deacetylase inhibitor TSA, resulted in increased FILIP1L mRNA in FILIP1L-low-expressing ovarian [3] and breast (Figure 4A) cancer cells, suggesting that DNA methylation, but not histone modification, is associated with the down-regulation of FILIP1L in these cells. Here, FILIP1L is linked to cancer.