Elevated levels of PTHrP were reported in a number of clinical myeloma cases, and recent studies by Cafforio et al. have found that both the full-length molecule and NH2-terminal fragment of PTHrP reinforces the production of osteoclastogenic factors RANKL and MCP-1, thus activate osteoclastogenesis [38]. The gene discussed is PTHLH; the disease is plasma cell myeloma.