LGR5 and adenoma: In fact, the level of Lgr5 expression in adenomas of 2 intestinal tumorigenesis mouse models, Apc1322T (1322T) and ApcR850X (Min), differed: 1322T tumors had higher Lgr5 expression levels than Min tumors, and more than half of the epithelial portion of the adenomas showed Lgr5 expression [14].