LGR5 and neoplasm: In addition to tumors with a basally restricted pattern of LGR5+ cells, we also observed adenomas with Lgr5+ cells that were dispersed throughout the tumor mass; this was not noted in a mouse study, in which approximately 5–10% of the tumor cells in most of the intestinal adenomas were Lgr5+ cells, which were mainly located at the basal areas of the tumor glands [7].