LGR5 and gastritis: Figure S3 shows an additional set of pictures of Lgr5+ cells in the gastric mucosa. Active gastritis with or without Helicobacter pylori infection had no effect on the Lgr5+ cell population (Fig. 2I). When counting the number of glands with Lgr5+ cells among 20 consecutive glands in both the gastric and intestinal mucosa, we surprisingly discovered that the frequency of glands with Lgr5+ cells in IM was almost as high as that in the small intestine (Fig. 2I), indicating that IM of the stomach seems to recapitulate intestinal mucosal features with regard to the stem cell population.