Similarly, assessment of the expression of ZO-1 (Figure 3C and 3D) and occludin (Figure 3E and 3F) demonstrated a significantly lower staining intensity for these proteins in the mature ethmoidal polyp tissue (Figure 3D, Figure 3F, respectively), compared to nasal mucosal tissue from controls (Figure 3C and 3E, respectively; p= 0.026 and p=0.041, respectively, Figure 4). The gene discussed is TJP1; the disease is polyp.