LRRK2 and Parkinson disease: We also identify one reported (R1441H) and two novel missense mutations (R767H and S885N) of LRRK2. Although the genome-wide association studies (GWAS) reported a strong association between LRRK2 genetic variations and PD [25,26], the GWAS association signal has not been driven by identified missense variant as the G2385R, which may be due to this risk variant is ethnic specific.