CRTAM and neoplasm: Although this T cell subpopulation exerted neither cytotoxicity nor cytokine secretion, an interaction of CRTAM on these cells with Necl-2 bearing tumor cells induced CRTAM down regulation and cell death of the Vγ9Vδ2 T cells, thus revealing the CRTAM involvement in the survival of activated Vγ9Vδ2 T cells [8].