CFLAR and cancer: It has been reported that IL-4/IL-4R interactions amplify the expression of some anti-apoptotic proteins, including PED/PEA15 (15 kDa phosphoprotein enriched in astrocytes), cFLIP/CFLAR (CASP8 and FADD-like apoptosis regulator), and the BCL family proteins Bcl-xL and Bcl, thereby preventing drug-induced cancer cell death [23], [24].