To date, no studies have been conducted to identify miRNAs that are regulated or affected by the expression of bcl-xL. As miRNAs are critical epigenetic apoptosis regulators in tumorigenesis, and cancer cells often have perturbed miRNA profiles that regulate cell survival, it is of interest to determine the role miRNAs play in the apoptotic properties of Bcl-xL silenced human lung adenocarcinoma cells. This evidence concerns the gene BCL2L1 and cancer.