[32] Another predictive gene identified in this study was BAG3 (BCL-2 associated athanogene 3) which is known to have anti-apoptotic effects in cancer cells and enhance resistance to chemotherapy. [33] The list of predictive genes we have identified may also provide insight and direction into the study of the biology of resectable metastatic colorectal cancer to the liver, as well as provide potential new targets for therapeutic development. This evidence concerns the gene BAG3 and cancer.