Fluorescent in situ hybridization (FISH) analyses performed on bone marrow cells of forty CML patients in chronic phase (CP) showed that the entire C22orf2 follows BCR and relocates to the derivative chromosome 9 (der (9q)) in patients with the typical t(9;22)(q34;q11) translocation or to the second fusion gene in patients with variant translocations. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.