MCF and CD34+ cells from four CML-CP patients, previously investigated for Cby1 expression, and HP were, therefore, compared for 5-methyl cytosine (5 mC) content at a C22orf2 promoter region encompassing the region −85 to +120. The gene discussed is CBY1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.