In this study, we report for the first time an increased urinary excretion of VTDB (Vitamin D binding protein), A2GL (Leucin-rich alpha-2-glycoprotein), AFAM (Afamin) and HEMO (Hemopexin) in patients with more severe IgA nephropathy, and suggest these proteins to be predictive biomarkers for severity of IgA nephropathy. The gene discussed is HPX; the disease is IgA glomerulonephritis.