Finally, CACNB2 is associated with the regulator of the voltage-gated calcium channels RIM1 [58], and with the sodium channel SCN2B, through its interaction with CACNA1B, since it has been described that a mutation in CACNB2b, and a mutation in SCN5A underlie cardiac conduction disease, as mentioned above [53].. The gene discussed is CACNB2; the disease is heart conduction disease.