DPYSL3 and familial pancreatic carcinoma: Since focal adhesion is known to regulate cell migration, we next investigated the role of DPYSL3 in pancreatic cancer cell migration and found acquisition of the enhanced motile phenotype in DPYSL3-introduced PANC-1 cells in vitro, as shown by a motility assay (Figure 4C) as well as a matrigel invasion assay (Figure 4D).