Thus, we demonstrated that delivery of synthetic (and functional) microRNA-155 (miR-155) specifically to CD11c+DEC205+MHC-II+ DCs in the microenvironment of ovarian cancer-bearing mice induced genome-wide transcriptional changes that were sufficient to transform these immunosuppressive leukocytes into an immunostimulatory cell type (37). This evidence concerns the gene ITGAX and ovarian cancer.