On the other hand, although the increase of memory CD8+ T cells was observed in DD-treated humanized mice after 4 or 7 dpi (Figure S5), here we particularly focused on the dynamics of HIV-1 infection during the acute phase (i.e., until 7 dpi) and observed a sharp increase of HIV-1 replication in DD-treated mice prior to the expansion of memory CD8+ T cells (Figure 7G). The gene discussed is CD8A; the disease is HIV-1 infection.