CD4 and disease arising from reactivation of latent virus: Using primary blood DC and resting CD4+ T cells we have demonstrated that: [1] co-culture of resting memory CD4+ T cells with DC can establish latent infection; [2] mDC but not pDC mediate this effect; [3] close cell-cell proximity is required between DC and T cells; and [4] multiple cell cycle genes were altered in non-proliferating CD4+ T cells, containing latently infected cells.