The secreted LOX acts on collagen and increases integrin activity, stimulating tumor cells to stretch pseudopodia protrusions with increased actin polymerization, focal adhesion formation, resulting in the enhancement of actomyosin- and cytomyosin-dependent cell contractility and migration, leaving behind remodeled matrix tracks as the "metastasis highway" for tumor cells to travel. The gene discussed is LOX; the disease is neoplasm.